File S1 - Evaluation of the Cost Effectiveness of Vesico-Amniotic Shunting in the Management of Congenital Lower Urinary Tract Obstruction (Based on Data from the PLUTO Trial)

Table S1 Resource use data. Details of resource use obtained directly from the clinical trial are shown. Table S2 Delivery Costs. Cost of delivery within the UK NHS (which were used in the cost estimation for the trial) are listed along with the appropriate Healthcare Resource Group (HRG) codes used to obtain these costs. Table S3 Admission and Transportation costs. Cost inputs for neonatal admission within the trial were estimated from published UK NHS tariffs. These are shown alongside the relevant HRG codes. Table S4 Cost of procedures. Costs of all the procedures carried out during the trial using the UK NHS tariffs are shown. HRG codes are also provided. Table S5 Cost of investigations. Costs of investigations used in the analysis are listed and the sources are made explicit. Table S6 Model inputs for the conservative arm of the trial. The inputs used for all three base case analyses (intention to treat, per protocol and uniform prior analyses) are shown. The inputs were derived from trial data. Table S7 Model inputs for the patients who had Vesico-Amniotic Shunt (VAS) placed and developed complications within the trial. All three base case analyses inputs are shown. Table S8 Model inputs for patients who had VAS placed but did not have complications. All base case analyses inputs are shown. Supplementary text: Details of the per protocol and uniform prior analyses are discussed.
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