RISK FACTORS AND PROGNOSTIC INDICATORS OF NEUROENDOCRINE COMPLICATIONS IN PRIMARY SCHOOL-AGED CHILDREN AFTER TRAUMATIC BRAIN INJURY

Neuroendocrine complications are increasingly recognized as significant long-term consequences of traumatic brain injury (TBI) in children. However, not all pediatric patients develop endocrine dysfunction, suggesting the presence of specific risk factors and prognostic indicators. This study aims to identify clinical and injury-related factors associated with the development of neuroendocrine complications in primary school-aged children following traumatic brain injury. A longitudinal observational study was conducted, focusing on injury severity, neuroimaging findings, and early hormonal changes. The results demonstrate that injury severity, repeated head trauma, and early hypothalamic-pituitary abnormalities are key predictors of neuroendocrine dysfunction. Early identification of high-risk patients allows targeted monitoring and preventive intervention.神经内分泌并发症已日益被认为是儿童创伤性脑损伤（traumatic brain injury, TBI）重要的远期后遗症。但并非所有儿科患者都会出现内分泌功能障碍，这提示存在特定的危险因素与预后指标。本研究旨在明确学龄儿童创伤性脑损伤后发生神经内分泌并发症相关的临床与损伤相关因素。 本研究采用纵向观察性研究设计，重点关注损伤严重程度、神经影像学表现与早期激素水平变化。研究结果显示，损伤严重程度、反复头部外伤以及早期下丘脑-垂体异常是内分泌功能障碍的关键预测因子。对高危患者的早期识别可实现针对性监测与预防性干预。