Ruthenium-BINAP Catalyzed Alcohol C–H <i>tert</i>-Prenylation via 1,3-Enyne Transfer Hydrogenation: Beyond Stoichiometric Carbanions in Enantioselective Carbonyl Propargylation
收藏NIAID Data Ecosystem2026-03-09 收录
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The chiral ruthenium complex formed in situ from (TFA)2Ru(CO)(PPh3)2 and (R)-BINAP is found to catalyze the enantioselective C–C coupling of diverse primary alcohols with the 1,3-enyne, TMSCCC(Me)CH2, to form secondary homopropargyl alcohols bearing gem-dimethyl groups. All reagents for this byproduct-free coupling are inexpensive and commercially available, making this protocol a practical alternative to stoichiometric carbanions in enantioselective carbonyl reverse prenylation.
创建时间：
2016-04-21
