A sensitive LC–MS/MS assay to quantitatefree payload Aur0101 from ADC PYX-201 inrat and monkey plasma: supplementary materials
收藏Taylor & Francis Group2024-05-16 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/A_sensitive_LC_MS_MS_assay_to_quantitatefree_payload_Aur0101_from_ADC_PYX-201_inrat_and_monkey_plasma_supplementary_materials/23967264/1
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Aim: Aur0101 is a cytotoxic and small-molecule microtubule depolymerizing agent, and is the payload conjugated to antibody–drug conjugate PYX-201. Developing and validating a sensitive bioanalytical method to quantitate Aur0101 was novel and crucial in preclinical PYX-201 studies. Materials & methods: Reference standard Aur0101 and its stable isotope labelled internal standard Aur0101-d8 were used in this LC–MS/MS method. Results: This sensitive assay was validated at a lower limit of quantitation of 15 pg/ml and successfully applied to support preclinical rat and monkey toxicology studies. Preclinical plasma toxicokinetic parameters were presented. Conclusion: A sensitive and robust LC–MS/MS assay was validated for Aur0101 in rat and monkey plasma.
提供机构：
Harriman, Shawn; Yin, Feng; Feng, Jianwen; Das, Biplab; Shaheen, Elizabeth; Sikora, Jack; Pinkas, Jan; Adhikari, Diana; Ahsan, Farah; Hahn, David; Zheng, Nancy; Amrite, Aniruddha; Wang, Frank
创建时间：
2023-08-16
