Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men

BackgroundWhether cigarette smoking and moderate drinking are associated with non-alcoholic fatty liver disease (NAFLD)has not been fully described. This study investigated the separate and joint effects of smoking and moderate drinking on Chinese men with NAFLD.MethodsAcross-sectional assay from DFTJ Cohort study was performed with a size of 9432 elderly Chinese men excluding excessive alcohol consumption (ResultsThe prevalence of NAFLD in current smokers (pack-year≥40) and drinkers (80~210g/week or drinking duration≥35years) was significantly higher than that in non-smokers and non-drinkers, respectively. The combination of current smoking (pack-year≥40) and drinking (80~210g/week) was associated with the highest risk of NAFLD (OR 1.85; 95% confidence interval [CI] 1.28–2.68;PPConclusionsIn elderly Chinese men, cigarette smoking and moderate alcohol consumption exerts an evident joint effect and interaction on the prevalence of NAFLD, although both are significantly and independently associated with NAFLD prevalence. Such findings highlight particular significance of avoidance of cigarette and alcohol on NAFLD prevention.研究背景：吸烟与适度饮酒是否与非酒精性脂肪性肝病（non-alcoholic fatty liver disease, NAFLD）相关，目前尚未得到充分阐明。本研究旨在探讨吸烟与适度饮酒对中国男性非酒精性脂肪性肝病的单独及联合影响。 研究方法：本研究基于DFTJ队列研究开展横断面分析，纳入9432名排除过量饮酒的中国老年男性受试者。 研究结果：当前吸烟量≥40包-年的吸烟者，与每周饮酒80~210g或饮酒时长≥35年的饮酒者，其非酒精性脂肪性肝病患病率均显著高于不吸烟者与不饮酒者。同时，当前吸烟≥40包-年且每周饮酒80~210g的人群，罹患非酒精性脂肪性肝病的风险最高（优势比（odds ratio, OR）=1.85；95%置信区间（confidence interval, CI）：1.28~2.68；原文此处存在疑似排版缺失内容）。 研究结论：尽管吸烟与适度饮酒均与非酒精性脂肪性肝病患病率显著独立相关，但在中国老年男性群体中，二者对该病患病率存在明确的联合效应与交互作用。本研究结果提示，规避吸烟与饮酒对非酒精性脂肪性肝病的预防具有重要意义。