PMACS-106 (in paper)

Project title: PMACS-106Grant Information: AHA Grant 9TPA34910007, Regulatory role of pericardial macrophages in myocardial infarctionRelevant Citations: https://doi.org/10.1016/j.isci.2024.110244Project Description:· Animal Model: IL-33 induced pericarditis· Animal Age: 6-8 Weeks· Animal Sex:· Animal Strain: C57B6/J LysCre or C57B6 LysCreGATA6fl/fl· Number: 10 Mice· Groups:o 5 LysCreo 5 LysCreGATA6fl/flo All received pericarditis injections· Experimental Conditions: All mice received IP injections of 1ug of IL-33 in 100uL of solution at day 0, 2, 4, 6 and 8. With each injection mice also received 100pmol/kg of IL-5. At day 10 mice sere sacrificed and hearts were processed for histologyLicenses: N/A项目名称：PMACS-106 资助信息：美国心脏协会（American Heart Association, AHA）资助项目编号9TPA34910007，研究主题为「心包巨噬细胞在心肌梗死中的调控作用」 相关文献：https://doi.org/10.1016/j.isci.2024.110244 项目描述： · 动物模型：白细胞介素33（Interleukin-33, IL-33）诱导性心包炎 · 实验动物周龄：6~8周 · 实验动物性别：未指定 · 实验动物品系：C57B6/J LysCre 或 C57B6 LysCreGATA6fl/fl · 实验动物总数：10只小鼠 · 实验分组： - LysCre组：5只 - LysCreGATA6fl/fl组：5只 - 两组均接受心包炎造模注射 · 实验方案：所有小鼠于第0、2、4、6、8天经腹腔（intraperitoneal, IP）注射100μL含1μg IL-33的溶液，每次注射同时按100pmol/kg的剂量注射白细胞介素5（Interleukin-5, IL-5）。第10天处死所有小鼠，取心脏进行组织学处理 授权情况：无适用授权