Proliferative verrucous leukoplakia: diagnosis, management and current advances

Abstract Introduction: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations. Objective: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. Methods: A Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with Proliferative verrucous leukoplakia was realized. Results: There are not enough studies about Proliferative verrucous leukoplakia in the literature. The few found studies not present a consensus about its etiology and diagnosis criteria. Although several treatment strategies have been proposed, most of them still show a high recurrence rate. Conclusion: More research about Proliferative verrucous leukoplakia is necessary to understand and treat this disease.摘要 引言：增殖性疣状白斑（Proliferative Verrucous Leukoplakia）是一种多灶性、进展性的口腔黏膜病损，病因尚未明确，通常对各类治疗手段均表现出抵抗性，且复发频繁。该病变具有较高的口腔鳞状细胞癌与疣状癌恶变率。 目的：分析现有关于增殖性疣状白斑的研究，并形成一份简明的最新综述。 方法：通过PubMed数据库检索针对增殖性疣状白斑患者的相关研究，涵盖实验室研究、病例系列及文献综述。 结果：目前文献中关于增殖性疣状白斑的研究数量匮乏。现有为数不多的相关研究尚未就其病因及诊断标准达成共识。尽管已提出多种治疗策略，但多数方案仍存在较高的复发率。 结论：需开展更多针对增殖性疣状白斑的研究，以深入认识并有效治疗该疾病。