Antimicrobial Peptide Database

The Antimicrobial Peptide Database (APD) was originally created by a graduate student, Zhe Wang, as his master's thesis in the laboratory of Dr. Guangshun Wang. The project was initiated in 2002 and the first version of the database was open to the public in August 2003. It contained 525 peptide entries, which can be searched in multiple ways, including APD ID, peptide name, amino acid sequence, original location, PDB ID, structure, methods for structural determination, peptide length, charge, hydrophobic content, antibacterial, antifungal, antiviral, anticancer, and hemolytic activity. Some results of this bioinformatics tool were reported in the 2004 database paper. The peptide data stored in the APD were gleaned from the literature (PubMed, PDB, Google, and Swiss-Prot) manually in over a decade.

抗菌肽数据库（APD）最初由王广顺博士实验室的硕士研究生王哲创建，作为其硕士学位论文的一部分。该项目始于2002年，并于2003年8月首次向公众开放。该数据库包含525个肽段条目，可通过对APD ID、肽段名称、氨基酸序列、原始位置、PDB ID、结构、结构确定方法、肽段长度、电荷、疏水含量、抗菌、抗真菌、抗病毒、抗癌和溶血活性等多种方式进行检索。此生物信息学工具的一些结果已在2004年的数据库论文中予以报道。APD中存储的肽段数据系通过十多年的时间，从文献（PubMed、PDB、Google和Swiss-Prot）中人工搜集而来。

搜集汇总

背景与挑战

背景概述

Antimicrobial Peptide Database（APD）是一个专注于抗菌肽和蛋白质的学科数据库，包含3,569个条目，其中3,067个为具有活性的天然抗菌肽。该数据库自2003年开放，提供多维度搜索功能，覆盖生命科学、医学等领域，数据为开放访问并遵循公共领域许可。