Dataset of the article entitled "Exploring the colloidal stability of curcumin nanoparticles formed by nanoprecipitation "

This dataset contains datas linked to the article "Exploring the colloidal stability of curcumin nanoparticles formed by nanoprecipitation ". Abstract of the article : Curcumin nanoparticles were prepared by antisolvent precipitation using acetone as the solvent and water as the antisolvent, offering a simple and food-compatible strategy to enhance curcumin dispersibility. The colloidal stability of the aqueous dispersions was assessed by static multiple light scattering, and particle size evolution over time was monitored by dynamic light scattering. Varying acetone content demonstrated the role of curcumin solubility in governing dispersion stability. Ostwald ripening was observed, with faster particle growth at higher acetone levels. A mathematical model inspired by the Lifshitz–Slyozov–Wagner (LSW) theory described the growth kinetics and allowed estimation of solubility-related parameters providing predictive insight into nanoparticles stability in aqueous environments and establishing a direct experimental validation of LSW-based modeling. Solubility measurements by HPLC were consistent with model-based estimates. Additional analyses revealed a solid-like amorphous state of the nanoparticles, as confirmed by solid-state 1H NMR and X-ray diffraction. These findings demonstrated that amorphous curcumin nanoparticles undergo Ostwald ripening in stabilizer-free aqueous systems, with ripening rates controlled by solvent-induced solubility changes.