SI Datasets S2-S6 associated to PNAS manuscript https://doi.org/10.1073/pnas.2200108119 : 'Molecular convergence by differential domain acquisition is a hallmark chromosomal passenger complex evolution'
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SI Datasets S2-S6 associated to PNAS manscript (https://doi.org/10.1073/pnas.2200108119): 'Molecular convergence by differential domain acquisition is a hallmark of the evolution of the chromosomal passenger complex'. Unzip files S2-S6 to access content. S2: AF2 predictions for BORI1 and BORI2, plus structural alignment pymol session file. S3: data and output file associated to Figure 1D S4: data and output file associated to Figure 8c S5: sequences of orthologues of INCENP, Borealin, Survivin/BORI and CPC2 + presence/absence matrix including an overview of the Histone H3 N-terminal tails. S6: Hidden Markov Models and lineage-specific alignments used for the iterative searches of the conserved helix that is also found in Survivin and BORI1/2.
本补充材料数据集S2-S6关联于发表于《美国国家科学院院刊》(PNAS)的学术论文(原文链接:https://doi.org/10.1073/pnas.2200108119),对应论文标题为《通过差异化结构域获得实现的分子趋同是染色体乘客复合体(chromosomal passenger complex)演化的标志性特征》。 解压S2至S6文件即可获取其中全部内容。 S2:包含BORI1与BORI2的AlphaFold2(AF2)预测结果,以及结构比对PyMOL会话文件。 S3:与图1D相关的数据集及输出文件。 S4:与图8c相关的数据集及输出文件。 S5:包含INCENP、Borealin、Survivin/BORI及CPC2的直系同源序列,以及涵盖组蛋白H3 N端尾区概况的存在/缺失矩阵。 S6:用于迭代搜索保守螺旋结构的隐马尔可夫模型(Hidden Markov Models)与谱系特异性比对数据,该保守螺旋结构同样存在于Survivin及BORI1/2中。




