Detection of Abnormal Serum PG and G-17.

BackgroundPepsinogen (PG) and gastrin-17 (G-17) are widely used in the screening of gastric diseases. Our cross-sectional clinical study investigates the relationship between Helicobacter pylori (HP) infection, sex, and age on serum levels of PG and G-17 in asymptomatic subjects in Rizhao, China.MethodsA total of 12,746 asymptomatic subjects were enrolled in the study between August 2023 and January 2024. Serum levels of pepsinogen I (PGI), pepsinogen II (PGII), and G-17 were measured using the chemiluminescent microparticle immunoassay method, and the PGI/PGII ratio (PGR) was calculated. HP infection was detected using the Colloidal Gold Method, and the relationship between age, sex, HP infection, and serum PG and G-17 levels was analyzed.ResultsHP prevalence was 19.33% in this study. The serum PGI, PGII, and G-17 levels were significantly higher in the HP-positive group compared to the HP-negative group (P ConclusionSerum levels of PG and G-17 are associated with HP infection, sex, and age. These findings provide region-specific insights into the relationships between these biomarkers and HP infection, highlighting the importance of considering HP infection status, sex, and age in future research.背景：胃蛋白酶原（pepsinogen，PG）与胃泌素-17（gastrin-17，G-17）是临床广泛应用的胃部疾病筛查标志物。本横断面临床研究旨在探讨中国日照地区无症状人群中，幽门螺杆菌（Helicobacter pylori，HP）感染、性别及年龄与血清PG和G-17水平之间的关联。 研究方法：本研究于2023年8月至2024年1月期间，共纳入12746名无症状受试者。采用化学发光微粒子免疫分析法（chemiluminescent microparticle immunoassay）检测血清胃蛋白酶原I（PGI）、胃蛋白酶原II（PGII）及G-17水平，并计算PGI/PGII比值（PGR）。采用胶体金法（Colloidal Gold Method）检测HP感染情况，进而分析年龄、性别、HP感染与血清PG及G-17水平之间的关联。 研究结果：本研究中HP感染率为19.33%。HP阳性组血清PGI、PGII及G-17水平均显著高于HP阴性组（P 研究结论：血清PG及G-17水平与HP感染、性别及年龄密切相关。本研究结果为该地区相关生物标志物与HP感染的关联提供了本土化视角，同时强调在未来相关研究中，需充分考虑HP感染状态、性别及年龄因素的重要性。