gene expression profiles in ankles from CAIA mice model. gene expression profiles in ankles from CAIA mice model

To identify a candidate epigenetic regulator in RA pathogenesis, gene expression microarray analysis was conducted using mRNA obtained from whole ankle tissue in collagen antibody-induced arthritis (CAIA) mice and two control mice (CtrlP and CtrlL) Overall design: collagen antibody induced arthritis (CAIA): 5 mg of anti-collagen 2 monoclonal antibody cocktail (Chondrex, USA, Redmond) was administered on day 0, followed by 50 μg of LPS on day 3 i.p. RNA was extracted from ankle tissues of Control, LPS control and CAIA mice.