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Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [array]

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE157530
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We used whole genome expression profiling to analyze the effects of Zika virus (ZIKV) strains Uganda and French Polynesia on the mRNA transcriptome of induced pluripotent stem cell-derived human neural stem cells (long-term self-renewing neuroepithelial-like stem (lt-NES®) cells) - particularly to identify differentially expressed genes which are associated with microcephaly phenotype. Gene expression profiles of Zika virus-infected lt-NES® cells were analyzed 24, 48 and 72 hours post infection. At the same timepoints gene expression profiles of uninfected lt-NES® cells were analyzed. 3 biological replicates were used.
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2021-02-12
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