Poor Endometrial Proliferation after Clomiphene is Associated with Altered Estrogen Action [ChIP-Seq]

We report ESR1 cistromic profiles from endometrial biopsies obtained from infertile women in the late proliferative phase who developed either optimal (≥8mm) or suboptimal (<6mm) endometrial thickness following early follicular phase exposure to 100mg clomiphene citrate for 5 days. ESR1 ChIP-seq was conducted on whole endometrium during the late proliferative phase. In parallel, RNA-seq analyses were conducted on whole endometrium during the late proliferative phase.