Keratinocytes derived from patient-specific iPSCs recapitulate the genetic signature of psoriasis disease

Induced pluripotent stem cells (iPSCs) were generated from control (Ctrl) and two psoriasis patients (PsO1 and PsO2) having genetic background of psoriasis. The iPSCs were differentiated into epidermal keratinocytes as described in the article entitled "Keratinocytes derived from patient-specific iPSCs recapitulate the genetic signature of psoriasis disease" by Gowher et al. The dataset represent RNA-seq data generated from keratiocytes derived from ctrl-iPSCs and psoriasis patients iPSCs (PsO1 and PsO2). The file name is : Sample name with replicate_overall sample number_read direction_001 where: - Ctrl Rep1 and Ctrl Rep2: Keratinocytes derived from control (Ctrl-iPSCs). - PSO1 Rep1 and PSO1 Rep2: Keratinocytes derived from psoriasis patient iPSCs (PSO1-iPSCs) - PSO2 Rep1 and PSO2 Rep2: Keratinocytes derived from psoriasis patient iPSCs (PSO2-iPSCs). - RNA-seq data was generated from two biological repliicates (Rep1 and Rep2). - Read direction: R1 (Forward), R2 (Reverse).诱导多能干细胞（induced pluripotent stem cells，iPSCs）分别从健康对照样本（Ctrl）以及两名携带银屑病遗传背景的银屑病患者（PsO1与PsO2）中诱导生成。按照Gowher等人发表的题为"患者特异性诱导多能干细胞衍生的角质形成细胞重现银屑病的遗传特征"的研究论文所述方法，将上述iPSCs定向分化为表皮角质形成细胞。本数据集包含源自健康对照诱导多能干细胞（Ctrl-iPSCs）及银屑病患者诱导多能干细胞（PsO1-iPSCs、PsO2-iPSCs）的角质形成细胞的RNA测序（RNA-seq）数据。 文件命名格式为：样本名_重复组_总样本编号_测序方向_001，具体说明如下： - Ctrl Rep1与Ctrl Rep2：源自健康对照诱导多能干细胞的角质形成细胞 - PSO1 Rep1与PSO1 Rep2：源自银屑病患者PsO1的诱导多能干细胞的角质形成细胞 - PSO2 Rep1与PSO2 Rep2：源自银屑病患者PsO2的诱导多能干细胞的角质形成细胞 - 本次RNA测序设置了两个生物学重复（Rep1与Rep2） - 测序方向为R1（正向）、R2（反向）。