Base-Mediated Tunable Synthesis of 2‑Trifluoromethylated Furans and Dihydrofuranols: Extraordinary Stable in Sulfuric Acid

2-Trifluoromethylated furans and dihydrofuranols were tunably synthesized from the cyclization of β-ketonitriles with 3-bromo-1,1,1-trifluoroacetone mediated by bases. In addition, dehydration of dihydrofuranol compounds with concentrated sulfuric acid gave another 2-(trifluoromethyl)­furans isomer. The developed methodology exhibits an excellent functional group tolerance for both aromatic and aliphatic β-ketonitriles.在碱介导下，通过β-酮腈（β-ketonitriles）与3-溴-1,1,1-三氟丙酮（3-bromo-1,1,1-trifluoroacetone）的环化反应，可可控合成2-三氟甲基化呋喃（2-Trifluoromethylated furans）与二氢呋喃醇（dihydrofuranols）。此外，采用浓硫酸对二氢呋喃醇类化合物进行脱水处理，可得到另一类2-(三氟甲基)呋喃异构体。本研究所开发的合成方法对芳香族与脂肪族β-酮腈均展现出优异的官能团兼容性。