p53 suppresses MHC class II antigen presentation by the intestinal epithelium to protect intestinal stem cells upon radiation. p53 suppresses MHC class II antigen presentation by the intestinal epithelium to protect intestinal stem cells upon radiation

To investigate the role of p53 in radiation-induced gastrointestinal syndrome, we performed gene expression profiling analysis using data obtained from RNA-seq of small intestine tissues from WT and p53-/- mice at 1 day post 12Gy total-body irradiation. Overall design: Comparative gene expression profiling analysis of RNA-seq data of small intestine tissues from WT and p53-/- mice at 1 day post 12Gy total-body irradiation.