Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)butane 1-phosphate

Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)butane 1-phosphate Descriptor: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 4-{2,6,8-TRIOXO-9-[(2R,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, 4-{2,6,8-TRIOXO-9-[(2S,3R,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, ... Authors: Morgunova, E, Meining, W, Illarionov, B, Haase, I, Fischer, M, Cushman, M, Bacher, A, Ladenstein, R. Deposit date: 2004-07-01 Release date: 2005-03-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,) Biochemistry, 44, 2005

结核分枝杆菌（Mycobacterium tuberculosis）鲁米诺合酶（Lumazine Synthase）与3-(1,3,7-三羟基-9-D-核糖基-2,6,8-嘌呤三酮-7-基)丁烷1-磷酸结合复合物数据集描述：(4S,5S)-1,2-二噻烷-4,5-二醇、4-{2,6,8-三氧代-9-[(2R,3S,4R)-2,3,4,5-四羟基戊基]-1,2,3,6,8,9-六氢-7H-嘌呤-7-基}丁基二氢磷酸酯、4-{2,6,8-三氧代-9-[(2S,3R,4R)-2,3,4,5-四羟基戊基]-1,2,3,6,8,9-六氢-7H-嘌呤-7-基}丁基二氢磷酸酯…… 作者：Morgunova E、Meining W、Illarionov B、Haase I、Fischer M、Cushman M、Bacher A、Ladenstein R。存放日期：2004年7月1日，发布日期：2005年3月3日，最后修改日期：2024年5月8日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.3埃（Å）。引用文献：《作为合理药物设计靶点的结核分枝杆菌鲁米诺合酶晶体结构：一类新型嘌呤三酮抑制剂的结合模式》，《生物化学（Biochemistry）》，第44卷，2005年