Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma [scRNA-seq]. Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma [scRNA-seq]

In this study, we examine the effect of radiation on the transcriptional profile of medulloblastoma tumor cells and its microenvironment that could potentially be leading to metastatic dissemination. Overall design: Cerebellar tumors from SmoA1 mice treated with radiation (1Gy) were collected at 5h and 24h after treatment and compared to sham-radiated controls by single cell RNA sequencing