High fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice. mice obesity

We used C57BL/6JBomTac (BL6) and 129S6/SvEvTac (Sv129) mice, known as obesity prone and obesity resistant, respectively, to dissociate changes in the gut microbiota associated with HF feeding from those associated with obesity. Using HiSeq-based whole genome sequencing we identified taxonomic and functional differences in the gut microbiota of the two mouse strains fed regular low fat or HF diets. HF feeding rather than obesity development led to distinct changes in the microbiota.