官方服务：
资源简介：
Amplicon sequencing of repair of targeted double strand DNA breaks.
应用场景：
创建时间：
2020-11-14
相关数据集
Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks
Genomic instability is a known precursor to cancer and aging. The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in maintaining genome stability in all livi
NIAID Data Ecosystem70
Homo sapiens Clone ends
Impact of A3G on non-homologous end-joining (NHEJ) of double-strand break repair
NIAID Data Ecosystem60
Cancer Cell Resistance to IFN? Can Occur via Enhanced Double-Strand Break Repair Pathway Activity [CRISPR screen]
The pleiotropic cytokine interferon-gamma (IFN?) is known to be associated with cytostatic, anti-proliferation, and pro-apoptosis functions in cancer cells. However, cancer cells can become resistant
NIAID Data Ecosystem40
DNA end-joining catalyzed by human cell-free extracts
Mammalian cells defective in DNA end-joining are highly sensitive to ionizing radiation and are immunodeficient because of a failure to complete V(D)J recombination. By using cell-free extracts prepar
PubMed Central1998-11-24 更新60
53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ
53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient
NIAID Data Ecosystem40
