Nutritional supplement study in healthy prediabetic subjects. A nutritional supplement based on a synbiotic combination of Bacillus subtilis DSM 32315 and L-alanyl-L-glutamine improves glucose metabolism in healthy prediabetic subjects - A real-life post-marketing study

Impaired glucose homeostasis is a major risk factor for cardiometabolic diseases, whereas the efficacy of available standard therapies is limited mainly because of compliance issues. This study assessed the glucose-lowering potential of a synbiotic-based formulation. 192 participants were enrolled in a digital nutrition program with continuous glucose measurement (CGM) and taking a study product comprising Bacillus subtilis DSM 32315 and L-alanyl-L-glutamine. Participants underwent a first sensor phase using CGM without supplementation, followed by a 14-day supplementation phase without sensor and completed by a second sensor phase while continuing supplementation. Fasting glucose levels were determined before and after supplementation by CGM. In addition, postprandial glycemic response to an oral glucose challenge, body weight, HbA1c concentrations, and BMI were analyzed. Subgroup analyses of subjects with elevated glucose and HbA1c level vs. normoglycemic were performed.