Clustering of the altered genes in response to TLR1/2 or TLR4 activation in SZ95 sebocytes.

Genes that were regulated both by PAM3CSK4 and LPS were functionally categorized using the Cytoscape classification system. The clusters clearly defined an immunocompetence for the activated sebocytes and pointed on so far unrevealed functions such as a possible involvement in wounding and leukocyte migration. Note that in black are the genes/clusters present in both the early (6 hours) as well as in the late responder (24 hours) group, while the genes in bold falling to the functional category of cholesterol metabolic process were only detected at 24 hours.