IMC Diabetes dataset (Damond et al.)

The IMC dataset generated by Damond et al. longitudinally profiles pancreatic tissue samples obtained from 67 human donors, including both non-diabetic individuals and patients diagnosed with Type 1 diabetes (T1D). The dataset is comprised of 33 non-diabetic controls and 34 donors with established long-standing T1D. Long-standing T1D represents patients with prolonged disease duration following diagnosis, typically characterized by sustained autoimmune-mediated β-cell depletion and chronic inflammatory remodeling of the pancreatic microenvironment. The IMC panel stained for 38 proteins.由Damond等人构建的IMC数据集（Imaging Mass Cytometry，成像质谱流式细胞术）对67名人类供者的胰腺组织样本开展了纵向表征分析，研究对象涵盖非糖尿病个体与确诊为1型糖尿病（Type 1 Diabetes，T1D）的患者。该数据集包含33名非糖尿病对照个体与34名确诊为长期1型糖尿病的供者。长期1型糖尿病指确诊后病程迁延的患者群体，其典型特征为持续的自身免疫介导的β细胞耗竭，以及胰腺微环境的慢性炎症重塑。该IMC检测面板共靶向检测了38种蛋白质。