Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid Authors: Keough, D.T, Hockova, D, Janeba, Z, Wang, T.-H, Naesens, L, Edstein, M.D, Chavchich, M, Guddat, L.W. Deposit date: 2014-09-10 Release date: 2015-01-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents. J.Med.Chem., 58, 2015

含第二个膦酸酯基团的氮杂无环核苷膦酸酯类作为人类、恶性疟原虫与间日疟原虫6-氧代嘌呤磷酸核糖转移酶的抑制剂及其作为抗疟剂的前药
描述符：次黄嘌呤-鸟嘌呤磷酸核糖转移酶（Hypoxanthine-guanine phosphoribosyltransferase）、镁离子（MAGNESIUM ION）、[(2-{[2-(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)乙基][(E)-2-膦酰乙烯基]氨基}乙氧基)甲基]膦酸
作者：Keough, D.T、Hockova, D、Janeba, Z、Wang, T.-H、Naesens, L、Edstein, M.D、Chavchich, M、Guddat, L.W.
入库日期：2014-09-10
发布日期：2015-01-07
最后修改日期：2024-02-28
检测方法：X射线衍射（2.05 Å）
引用文献：《含第二个膦酸酯基团的氮杂无环核苷膦酸酯类作为人类、恶性疟原虫与间日疟原虫6-氧代嘌呤磷酸核糖转移酶的抑制剂及其作为抗疟剂的前药》，J. Med. Chem., 58, 2015