Associations of joint GlycA and hsCRP levels and cardiovascular events in 4,759 participants (298 events) of the PREVEND study.

Higher levels were defined as greater than the upper quartile, GlycA >387 μmol/L and hsCRP >2.95 mg/L.Multivariable model 1: Crude + age, sex.Multivariable model 2: Model 1 + BMI, alcohol intake, smoking status, diabetes mellitus type 2, lipid lowering drugs, anti-hypertensive medications and systolic blood pressure, total cholesterol, HDL cholesterol, triglycerides, eGFRcrea-cysC and UAE.Triglycerides, UAE and hsCRP were log transformed when used as a continuous variable in the analyses.Abbreviations: BMI, body mass index; HDL-cholesterol, high density lipoprotein cholesterol; eGFRcrea-cysC, estimated glomerular filtration rate based on creatinine-cystatin C equation; hsCRP, high-sensitivity C-reactive protein; UAE, urinary albumin excretion.Associations of joint GlycA and hsCRP levels and cardiovascular events in 4,759 participants (298 events) of the PREVEND study.更高水平定义为大于上四分位数，即糖蛋白A（GlycA）>387 μmol/L且高敏C反应蛋白（hsCRP）>2.95 mg/L。多变量模型1：校正年龄与性别。多变量模型2：在模型1的基础上，额外校正体质指数（BMI）、饮酒量、吸烟状态、2型糖尿病、调脂药物、降压药物、收缩压、总胆固醇、高密度脂蛋白胆固醇（HDL胆固醇）、甘油三酯、基于肌酐-半胱氨酸蛋白酶抑制剂C方程的估算肾小球滤过率（eGFRcrea-cysC）以及尿白蛋白排泄量（UAE）。分析过程中，若将甘油三酯、尿白蛋白排泄量（UAE）及高敏C反应蛋白（hsCRP）作为连续变量纳入分析，则需对其进行对数转换。缩写说明：BMI（body mass index）为体质指数；HDL-cholesterol（high density lipoprotein cholesterol）为高密度脂蛋白胆固醇；eGFRcrea-cysC（estimated glomerular filtration rate based on creatinine-cystatin C equation）为基于肌酐-半胱氨酸蛋白酶抑制剂C方程的估算肾小球滤过率；hsCRP（high-sensitivity C-reactive protein）为高敏C反应蛋白；UAE（urinary albumin excretion）为尿白蛋白排泄量。本研究针对PREVEND队列的4759名参与者（其中发生心血管事件者298例），分析了联合糖蛋白A（GlycA）与高敏C反应蛋白（hsCRP）水平与心血管事件的关联。