Additional file 1 of Prioritization of therapeutic targets for cancers using integrative multi-omics analysis

Additional file 1. Table S1. The information of outcomes resources. Table S2. The information of exposures resources. Table S3. The information of TWAS-significant genes in whole blood. Table S4. Results of SMR for genes associated with cancers in whole blood. Table S5. Results of colocalization for the genes signficantly associated wtith cancers in TWAS and SMR analysis in whole blood. Table S6. The information of TWAS-significant genes in specific organ tissues. Table S7. Results of SMR for genes associated with cancers in specific organ tissues. Table S8. Results of colocalization for the genes signficantly associated wtith cancers in TWAS and SMR analysis in specific organ tissues. Table S9. The information of PWAS-significant genes in whole blood. Table S10. Results of MR for protein-code genes associated with cancers in whole blood. Table S11. Results of colocalization for protein-code genes signficantly associated wtith cancers in PWAS and MR analysis in whole blood. Table S12. The list of druggable genes for SMR. Table S13. Results of SMR for druggable genes associated with cancers. Table S14. Results of colocalization for identified druggable genes wtith cancers in FinnGen cohort. Table S15. Results of phenotype scanning on candidate genes. Table S16. The information of enrichment analysis for candidate genes. Table S17. Results of enrichment analysis for candidate genes. Table S18. The information of metabolic pathways. Table S19. The information of IVs for Metabolome-wide Mendelian Randomization on cancers. Table S20. Results of Metabolome-Wide Mendelian Randomization on cancers.附加文件1。表S1：结局资源信息。表S2：暴露资源信息。表S3：全血中全转录组关联分析（Transcriptome-Wide Association Study, TWAS）显著基因信息。表S4：全血中与癌症相关基因的基于汇总数据的孟德尔随机化（Summary-based Mendelian Randomization, SMR）分析结果。表S5：全血中经全转录组关联分析与基于汇总数据的孟德尔随机化分析均显著关联癌症的基因的共定位分析结果。表S6：特定器官组织中全转录组关联分析显著基因信息。表S7：特定器官组织中与癌症相关基因的基于汇总数据的孟德尔随机化分析结果。表S8：特定器官组织中经全转录组关联分析与基于汇总数据的孟德尔随机化分析均显著关联癌症的基因的共定位分析结果。表S9：全血中蛋白质组全关联分析（Protein-Wide Association Study, PWAS）显著基因信息。表S10：全血中与癌症相关的蛋白编码基因的孟德尔随机化（Mendelian Randomization, MR）分析结果。表S11：全血中经蛋白质组全关联分析与孟德尔随机化分析均显著关联癌症的蛋白编码基因的共定位分析结果。表S12：可药用基因列表（针对基于汇总数据的孟德尔随机化分析）。表S13：与癌症相关的可药用基因的基于汇总数据的孟德尔随机化分析结果。表S14：芬根队列（FinnGen cohort）中经鉴定的可药用基因与癌症的共定位分析结果。表S15：候选基因的表型扫描结果。表S16：候选基因富集分析相关信息。表S17：候选基因富集分析结果。表S18：代谢通路相关信息。表S19：癌症代谢组全孟德尔随机化分析的工具变量（Instrumental Variables, IVs）相关信息。表S20：癌症代谢组全孟德尔随机化分析结果。