Evaluation of simvastatin activity in the mevalonate pathway in Staphylococcus aureus
收藏REDU2025-01-01 更新2026-05-11 收录
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https://redu.unicamp.br/citation?persistentId=doi:10.25824/redu/KNWSFL
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资源简介：
This study investigated the antimicrobial mechanism of simvastatin, a cholesterol-lowering drug that has shown in vitro activity against Staphylococcus aureus. The focus was on the bacterial HMG-CoA reductase, a enzyme player in the mevalonate pathway. The enzyme from S. aureus was cloned, expressed in E. coli, and purified for enzymatic assays. Molecular modeling studies were performed using AlphaFold 3 and molecular docking to explore the interaction between simvastatin and the active site of the bacterial enzyme.
提供机构：
. Faculdade de Ciências Farmacêuticas); . Instituto de Biologia); , Faculdade de Odontologia de Piracicaba)
创建时间：
2025-01-01
