Secondary hypoparathyroidism to omeprazole prolonged use in a dog: case report

ABSTRACT Primary or secondary hypoparathyroidism is a rare disease in dogs caused by the decreased secretion of parathormone from the parathyroid glands, leading to clinical signs of hypocalcemia. Omeprazole has been increasingly used in veterinary medicine in order to reduce the production of cerebrospinal fluid, but there are few reports of side effects related to its chronic use. We report a case of a four-year-old male Yorkshire terrier with clinical signs of pain, calcification in the pelvis and renal diverticulum. According to the owner, the dog had been receiving omeprazole for over 2 years because of the history of hydrocephalus. Hematological exams revealed hypochromic microcytic anemia, hypokalemia, hyperphosphatemia, hypocalcemia, hypomagnesemia besides hypercalciuria. The determination of serum parathyroid hormone concentrations confirmed hypoparathyroidism. After interrupting omeprazole, the altered features on the exams returned to normal values, confirming that the cause of hypoparathyroidism was the chronic use of the drug.

摘要：原发性或继发性甲状旁腺功能减退症（hypoparathyroidism）是犬类罕见疾病，由甲状旁腺（parathyroid glands）分泌甲状旁腺激素（parathormone）减少引发，可导致低钙血症相关临床症状。奥美拉唑（omeprazole）在兽医学中的应用日渐广泛，主要用于减少脑脊液（cerebrospinal fluid）生成，但关于其长期使用所致不良反应的报道仍较为少见。本病例报告一例4岁公约克夏㹴，该犬出现疼痛、骨盆及肾憩室钙化的临床症状。据犬主介绍，该犬因脑积水病史已连续服用奥美拉唑超过2年。血液学检查结果显示，除高钙尿症外，该犬还存在低色素小细胞性贫血、低钾血症、高磷血症、低钙血症及低镁血症。血清甲状旁腺激素浓度测定确诊为甲状旁腺功能减退症。停用奥美拉唑后，各项异常检查指标均恢复至正常水平，证实该犬的甲状旁腺功能减退症系长期用药所致。