Risk of cancers assessed by the modified intention to treat model and by the per protocol model.

Abbreviations: mITT, modified intention to treat; NDA, New drug Approval; NMSC, non-melanoma skin cancers; OR, odds ratio; 95% CI, 95% confidence interval;*14 trials included for overall cancer analysis.†7 trials included for overall cancer analysis.‡The trial by Miyasaka et al. was excluded from these analyses for the two cancers that occurred in the placebo arm were not otherwise specified.§These analyses excluded two trials: the one by Miyasaka et al. (because the two cancers that occurred in the placebo arm were not otherwise specified) and the one by Weisman et al. (because the three skin cancers that occurred were not otherwise specified).¶Publication bias.缩略语说明：mITT：修正意向治疗（modified intention to treat）；NDA：新药批准（New drug Approval）；NMSC：非黑色素瘤皮肤癌（non-melanoma skin cancers）；OR：比值比（odds ratio）；95% CI：95%置信区间（95% confidence interval）；*14项试验被纳入总体癌症分析。†7项试验被纳入总体癌症分析。‡Miyasaka等人的研究因安慰剂组中发生的2种癌症未明确具体类型，被排除于上述两项癌症的分析之外。§本次分析排除了两项试验：一是Miyasaka等人的研究（因安慰剂组中发生的2种癌症未明确具体类型），二是Weisman等人的研究（因发生的3种皮肤癌未明确具体类型）。¶发表偏倚。