File S1 - Effects of Candesartan on Electrical Remodeling in the Hearts of Inherited Dilated Cardiomyopathy Model Mice

Figure S1. Effects of hydralazine on ECG data. A. Typical traces of ECG from WT and Hydralazine treated DCM mice. B. Comparison of QRS (upper panel) and QTc (lower panel) intervals. Data with WT, untreated control and candesartan-treated DCM mice are same as those in Fig. 2B. n = 7 for hydralazine. *P†PFigure S2. Effects of candesartan treatment on expression levels of mRNA encoding K+ channels and accessory subunit in WT left ventricle. Quantitative real-time PCR analysis was carried out with LVs from control WT (n = 10) and candesartan-treated WT (n = 8) mice. The GAPDH gene was used as an internal control. Figure S3. Current kinetics of Ito (A and C) and IKur(B and D). Time to peak (A and B) and decay time (100 to 50% of peak) (C and D) are plotted against membrane capacitance. Cm was poorly correlated with current kinetics of Ito or IKur. Figure S4. Typical images of myocytes obtained with 60× objective lens. A. WT, B. Candesartan treated DCM. C. Control DCM. (PDF)