India ICEMR Cross-sectional

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Background: This dataset presents a cross-sectional study performed at 3 different sites in India: Chennai, Rourkela, and Nadiad, with matching census data for participants.

Objectives:

Establish the prevalence and incidence of malaria
Determine the impact of complex malaria on disease outcome
Determine the impact of the host immune response to functionally important antigens

Methodology:

Geographic Location/Study Sites: Chennai in the state of Tamil Nadu, Rourkela in Sundargarh District in the state of Odisha, and Nadiad in the state of Gujarat

Dates of Data Collection: Census data was collected between January 2012 and October 2014. Cross-sectional surveys were conducted 4 times over 2 years between December 2012 and November 2014.

Study Design: Cross-sectional study

Eligibility Criteria: Cross-sectional survey participants were identified randomly from census household members from each site.

Data Collection: Census information was collected once from households in Chennai in Tamil Nadu, Rourkela in Odisha, and Nadiad in Gujurat. The survey included questions on household members and facilities, household assets, animals, bednet and insecticide usage.

Each enrolled participant answered questions from a detailed clinical questionnaire on demographics, malaria history, use of mosquito protection, recent travel history, and current symptoms. They also underwent a physical exam and blood collected from a finger prick for malaria diagnosis by microscopy, RDT, and PCR, and for downstream analyses such as host or parasite genotyping, or seropositivity studies. A larger volume of blood was collected from RDT positive subjects for additional studies such as parasite whole genome sequencing. There was a follow-up visit within two weeks for participants who tested positive for malaria.

Note: only census data linked to participants in the cross-sectional study is displayed in ClinEpiDB.

Study Documentation:

Census CRF - Used to collect census data at the household and individual level
Cross-sectional enrollment CRF - Used to enroll participants in the cross-sectional study and collect participant and observation level data
Follow-up visit CRF - Used to collect data at a follow-up visit if the participant was found to have malaria during the original visit
Data dictionary - Contains the variable names and possible values for all CRFs along with the questions being asked and data types

ClinEpiDB Data Integration: Data files were provided to ClinEpiDB as flat, csv files. These datasets were merged by unique ID and redundant or administrative columns were dropped from presentation on ClinEpiDB.org. All dates were obfuscated per participant through the application of a random number algorithm that shifted dates no more than seven days to comply with the ethical conduct of human subjects research.

Acknowledgements: We gratefully acknowledge the Director, field officers, and staff of the Indian Council of Medical Research/National Institute of Malaria Research, and the peoples of Chennai, Rourkela, and Nadiad, India.

Financial Support: Supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number U19AI089676.

Ethics Statement: Ethical approval to conduct this study was obtained from the Indian Council of Medical Research/ National Institute of Malaria Research, and the Institutional Review Board of New York University. All project staff completed Protection of Human Research Subjects training prior to beginning the study, and clinical samples were collected after informed consent was obtained from participants.

Last updated: December 23, 2021
A cross-sectional study of malaria in different transmission settings was conducted in India. Participants of all ages were randomly identified from household censuses that were conducted and surveyed once. Participants had follow-up visits if they were positive for Plasmodium at the first visit.