Identification of HIV-1 exposure factors through a predictive model of HIV-1 transmission.

Baseline data from non-transmitting and linked transmitting couples from the Partners in Prevention HSV/HIV Transmission Study (N = 3360) was used to develop a predictive Cox regression model of HIV-1 transmission. An exposure risk score based on model regression coefficients was developed to quantify exposure risk and confirm that participants selected for GWAS testing who had not seroconverted did have HIV-1 exposure.