A conserved RNA-binding protein Celf1 controls cell differentiation in vertebrate eye development. Mus musculus

Celf1 germline or conditional deletion mouse mutants exhibit fully penetrant lens defects including cataract. To gain insight into gene expression changes underlying these lens defects, microarray comparison was performed for lenses obtained from wild-type and Celf1 conditional deletion mutant mice. At ±2.0 fold-change cut-off (p<0.05), 102 genes were identified to be differentially expressed in Celf1 conditional mutant lenses Overall design: Microarray comparison of lenses from mixed background (C57BL/6J, FVB) wild-type and mutant (Celf1cKO/lacZKI; Pax6GFPCre) mice was performed