Regulation of male fertility and accessory gland gene expression by the Drosophila DHR39 nuclear receptor
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Here we show that the Drosophila nuclear receptor DHR39 is necessary for male reproduction and acts as a global regulator of accessory gland gene expression. Mutants for the DHR39 transcription factor are sterile, with the majority of accessory gland genes expressed at reduced levels. Specific depletion of DHR39 within the accessory gland is sufficient to reduce male fecundity and accessory gland gene expression. Restoration of DHR39 in the accessory gland of DHR39 mutants rescues this sterility and transcriptional reduction. We conclude that DHR39 is a key regulator of most accessory gland genes, including ovulin and sex peptide, and is necessary for male fertility.
提供机构：
University of Utah
创建时间：
2022-02-20
