The accession numbers for the 100 high-frequency DBLα types and their number of occurrences in the dataset (i.e., counts).

These high-frequency DBLα types were each used to BLAST query a globally assembled var gene database [5] and representative hit subject sequences with the BLAST results are included along with the domain structure arrangement of the representative hit and other high identity hits, e.g. the structure NTSB3-DBLα0.2-CIDRα3.3- DBLγ1- CIDRβ1 indicates that most of the highly ranked hits had this exact structure so the gene was conserved whereas NTSB3-DBLα0.9/0.11/0.16-CIDRα2.1/2.4/3.4 indicates that three DBLα types and three CIDRα types were represented in the highly ranked hits and therefore this DBLα type was not part of a highly conserved gene structure. Conserved structures previously identified domain cassettes (DC) [6] and their association with disease are indicated. The global var assembly included clusters of highly conserved var genes that were associated with selective sweeps on chromosomes 4, 6 and 7. Any of the high-frequency DBLα types that were homologues of genes from these clusters are indicated (selective sweep associated chromosome) and a member of the cluster from an assembled P. falciparum genome that was used to assign the chromosome to the cluster is included along with positional information relative to other assembled genome homologues of types associated with the sweeps that were also identified in the current study. (CSV)