The accession numbers for the 100 high-frequency DBLα types and their number of occurrences in the dataset (i.e., counts).
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These high-frequency DBLα types were each used to BLAST query a globally assembled var gene database [5] and representative hit subject sequences with the BLAST results are included along with the domain structure arrangement of the representative hit and other high identity hits, e.g. the structure NTSB3-DBLα0.2-CIDRα3.3- DBLγ1- CIDRβ1 indicates that most of the highly ranked hits had this exact structure so the gene was conserved whereas NTSB3-DBLα0.9/0.11/0.16-CIDRα2.1/2.4/3.4 indicates that three DBLα types and three CIDRα types were represented in the highly ranked hits and therefore this DBLα type was not part of a highly conserved gene structure. Conserved structures previously identified domain cassettes (DC) [6] and their association with disease are indicated. The global var assembly included clusters of highly conserved var genes that were associated with selective sweeps on chromosomes 4, 6 and 7. Any of the high-frequency DBLα types that were homologues of genes from these clusters are indicated (selective sweep associated chromosome) and a member of the cluster from an assembled P. falciparum genome that was used to assign the chromosome to the cluster is included along with positional information relative to other assembled genome homologues of types associated with the sweeps that were also identified in the current study. (CSV)
本研究中，每一类高频DBLα型（DBLα types）均被用于对全局组装的var基因数据库[5]执行BLAST查询。BLAST结果中的代表性命中靶序列，连同该代表性命中结果的结构域排布及其他高同源性命中结果的结构域排布，均已纳入标注。例如，结构NTSB3-DBLα0.2-CIDRα3.3-DBLγ1-CIDRβ1表明，多数排名靠前的命中结果均携带该完全一致的结构域排布，提示该基因属于保守型基因；而结构NTSB3-DBLα0.9/0.11/0.16-CIDRα2.1/2.4/3.4则显示，排名靠前的命中结果中涵盖三类DBLα型与三类CIDRα型，因此该DBLα型并非高度保守基因结构的组成部分。此前已被鉴定的保守结构域盒（domain cassettes, DC）[6]及其与疾病的关联均已完成标注。该全局var基因组装集包含了与4号、6号及7号染色体上的选择性清除（selective sweep）相关的高度保守var基因簇。所有属于上述基因簇基因同源物的高频DBLα型均已标注（关联选择性清除的染色体）；同时纳入了来自组装完成的恶性疟原虫（*Plasmodium falciparum*）基因组的该基因簇成员——该成员被用于将染色体分配至对应基因簇，并附带了与本研究中同样被鉴定出的、与选择性清除相关的其他组装基因组同源序列的位置信息。(CSV)
