Supplementary Material for: Acetazolamide-Induced Bilateral Uveal Effusions and Secondary Angle Closure: A Case Report

Introduction: Acetazolamide-induced uveal effusion and secondary angle closure is a rarely reported but clinically significant phenomenon. The reaction is idiosyncratic and independent of dosage or prior exposure. Case Presentation: A 52-year-old patient developed severe bilateral uveal effusions, acute angle closure, and myopic shift 24 hours after commencing acetazolamide for altitude sickness prophylaxis. The case demonstrates unusually severe posterior involvement after a single prophylactic dose, with dramatic recovery following initiation of intravenous methylprednisolone. Conclusion: Given the widespread use of acetazolamide in ophthalmology and other medical disciplines, clinicians must be aware of potentially sight-threatening drug reactions. Prescription of acetazolamide for altitude sickness prophylaxis represents a unique risk, as patients are likely to be travelling to remote destinations. First-time dosing should occur where urgent medical assessment is readily accessible.引言：乙酰唑胺（acetazolamide）诱导的葡萄膜积液（uveal effusion）与继发性房角关闭是一种报道罕见但临床意义重大的现象。该反应为特异质反应，与给药剂量或既往用药暴露均无关。病例报告：一名52岁患者因预防高原病开始服用乙酰唑胺后24小时，出现严重双侧葡萄膜积液、急性房角关闭及近视漂移（myopic shift）。该病例显示单次预防剂量给药后即出现异常严重的后段眼部受累，经静脉给予甲泼尼龙（methylprednisolone）治疗后病情显著缓解。结论：鉴于乙酰唑胺在眼科及其他医学学科中应用广泛，临床医师需警惕这种可能威胁视力的药物不良反应。用于高原病预防的乙酰唑胺处方存在独特风险，因为患者往往会前往偏远地区。首次给药应在可及时获得急诊医疗评估的场所进行。