Comparison of short-term adverse events.

Mild adverse events were defined as complications resolving spontaneously within one hour and included rash (14 cases, 17.3%), pruritus (5 cases, 6.2%), nausea (9 cases, 11.1%) and headache (3 cases, 3.7%). In 11 out of 14 cases rashes were reported in the rhTNFR-Fc group. Moderate adverse events were defined as complications that may be immediately alleviated by medical interventions and included skin allergies (16 cases, 19.8%), fever (2 cases, 2.5%), palpitations (12 cases, 14.8%), dyspnea (2 cases, 2.5%), chest pain (1 case, 1.2%), abdominal pain (4 cases, 4.9%) and hypertension (9 cases, 11.1%). Severe adverse events were defined as fatal or requiring inpatient hospitalization and included papilledema (2 cases, 2.5%), laryngeal edema (1 case, 1.2%) and premature ventricular contraction (1 case, 1.2%). Comparison of short-term adverse events.