Structure and functional mapping of the KRAB-KAP1 repressor complex [KAP1_CUT&RUN-seq]
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https://www.ncbi.nlm.nih.gov/sra/SRP401507
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资源简介：
We used CUT&RUN to assess how abolition of KRAB binding by KAP1 (through structure-guided mutations in the KAP1-KRAB binding interface) changed the distribution of H3K9me3 epigenetic mark genome-wide. Overall design: Comparative H3K9me3 enirchment analysis of CUT&RUN-seq data for HEK293T cells and its derivatives [KAP1-KO, WTcomp (KAP1-KO cells complemented with a wild type KAP1), and CCmutComp (KO cells complemented with a KAP1-coiled coil mutant)]. Experiments were performed on HEK293T cells (n=2 for each condition)
创建时间：
2023-01-12
