Metabolomics in urine and serum of 4Gy exposed NHP (2 year followup)

Nonhuman primates exposed to total body irradiation of 4 Gy gamma were followed for two years after exposure. Urine and serum were collected at various time points up until 2 years after exposure, and appropriately age matched controls were identified for the later time points. Metabolomic analysis was conducted through untargeted metabolomics and metabolic fingerprinting, based on published radiation biomarkers. The radiation signal persisted for at least 2 years after exposure with high sensitivity and specificity.