Supplementary Material for: Drug Removal by Hemoadsorption

Background: There is growing interest in hemoadsorption (HA) therapies in critically ill patients although their precise indications remain to be established. Several devices are available on the market with heterogeneous properties and capabilities. Summary: Due to the non-specific removal associated with most HA techniques, concerns have been raised on their unintended removal of drugs such as anti-infectives in sepsis. On the other hand, drug removal might be beneficial in certain situations for instance antithrombotic medications in patients requiring emergency surgery or in case of accidental or self-induced intoxication. In this review, we summarize available in vitro, in vivo, and clinical studies reporting on the influence of various HA techniques on drugs pharmacokinetics. Key message: We conclude that further studies should aim at providing drug dosing recommendations during HA and confirm its safety, efficacy, and practicalities when used for intoxications.背景：尽管血液吸附（hemoadsorption, HA）疗法的确切适应证尚未明确，但目前重症患者对该疗法的关注度与日俱增。市场上已有多款特性与功能各异的HA设备可供使用。 概述：由于多数HA技术均存在非特异性清除效应，学界对其可能意外清除脓毒症患者体内抗感染药物等药物的问题提出了担忧。另一方面，在特定场景下药物清除或许有益，例如为需急诊手术的患者使用抗血栓药物，或是在意外或自服中毒的情况下。本综述总结了当前已发表的体外、体内及临床研究，这些研究均探讨了各类HA技术对药物药代动力学的影响。 核心观点：我们认为，未来的研究应致力于制定HA治疗期间的药物给药方案建议，并验证该疗法用于中毒救治时的安全性、有效性与实际应用可行性。