A Co(II)-based coordination polymer: inhibitory activity on cervical cancer cells
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https://tandf.figshare.com/articles/dataset/A_Co_II_-based_coordination_polymer_inhibitory_activity_on_cervical_cancer_cells/12859672
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By using a mixed-ligand approach, a new Co(II)-bearing coordination polymer (CP) with the chemical formula of [{Co(BINDI)<sub>0.5</sub>(bpa)<sub>0.5</sub>(H<sub>2</sub>O)}·4H<sub>2</sub>O]<i><sub>n</sub></i> (<b>1</b>, H<sub>4</sub>BINDI = <i>N</i>,<i>N</i>′-bis(5-isophthalic acid)naphthalenediimide, bpa = 1,2-bis(4-pyridyl)ethane) has been synthesized by room temperature self-assembly and structurally characterized successfully. Furthermore, a process of sonochemistry with oleic acid treatment at 453 K was used to produce the nanostructure <b>1</b> (denoted as nano <b>1</b> hereafter). The inhibitory effect of nano <b>1</b> on cervical cancer cells was determined. Firstly, the CCK-8 assay was performed. The Reverse Transcription Polymerase Chain Reaction (RT-PCR) assay was performed and the relative expression levels of miR-16-1 were determined. Then, the western blotting detection was conducted and the Bcl-2 expression level after nano <b>1</b> treatment was evaluated.
提供机构：
Taylor & Francis
创建时间：
2020-08-25
