In vivo antitrypanocidal activity in the GVR35-LUC2 mouse model.

aDoses were administered on consecutive days.bDay post-infection (p.i.) when positive bioluminescence was first detected is shown with number of mice indicated in brackets. The criterion for positive bioluminescence was set at total flux of the head image ≥3×105 photons per second.cMelarsoprol was applied topically to the back of the neck while the other compounds were injected intraperitoneally.d1/8 mice died 4 days after treatment, possibly due to toxicity.e1/6 mice was killed on day 44 p.i. due to hind leg paralysis.