In vivo antitrypanocidal activity in the GVR35-LUC2 mouse model.

aDoses were administered on consecutive days.bDay post-infection (p.i.) when positive bioluminescence was first detected is shown with number of mice indicated in brackets. The criterion for positive bioluminescence was set at total flux of the head image ≥3×105 photons per second.cMelarsoprol was applied topically to the back of the neck while the other compounds were injected intraperitoneally.d1/8 mice died 4 days after treatment, possibly due to toxicity.e1/6 mice was killed on day 44 p.i. due to hind leg paralysis.a. 给药方案为连续每日给药。 b. 首次检测到生物发光阳性的时间以感染后天数（Day post-infection, 缩写为p.i.）表示，对应小鼠的数量标注于括号内。生物发光阳性的判定标准设定为头部图像的总光子通量≥3×10^5 光子/秒。 c. 美拉胂醇（Melarsoprol）采用颈后部局部给药，其余受试化合物均采取腹腔注射给药。 d. 8只小鼠中有1只于给药后4天死亡，推测死因为药物毒性反应。 e. 6只小鼠中有1只于感染后第44天因后肢麻痹被处死。