Genome Wide Association Study of Asthma

This data forms part of an ongoing genome wide association study into the genetic variants that predispose to pediatric asthma at the Children's Hospital of Philadelphia (CHOP). All cases and controls were recruited at CHOP and genotyped at the Center for Applied Genomics (CAG). The data set includes 793 cases and 1988 controls. The inclusion criteria to this case control study are detailed below. ]]>
This is a genomewide association study involving children with asthma. The samples included 793 North American children of European ancestry with persistent asthma who require daily inhaling glucocorticoid therapy and 1988 matched controls (the discovery set). The study was also tested for genomewide association in an independent cohort of 917 persons of European ancestry who had asthma and 1546 matched controls (the replication set). Finally, it was tested for an association between 20 single-nucleotide polymorphisms (SNPs) at chromosome 1q31 and asthma in 1667 North American children of African ancestry who had asthma and 2045 ancestrally matched controls.Inclusion Criteria: Cases: Childhood onset persistent asthma requiring daily inhaled glucocorticoids for symptom control. Controls: No history of asthma or other respiratory diseases. Cases and Controls: North American of European ancestry (EA). ]]>
Results of the association study are detailed in the publication below.]]>