Long-term dietary flavonoid intake and subjective cognitive decline in US men and women

Objective: To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD).

Methods: We followed 49,493 women from the Nurses’ Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids, and proanthocyanidins) and subsequent SCD. For the NHS, long-term average dietary intake was calculated from seven repeated food frequency questionnaires (SFFQs), and SCD was assessed in 2012 and 2014. For the HPFS, average dietary intake was calculated from five repeated SFFQs, and SCD assessed in 2008 and 2012.

Results: Higher intake of total flavonoids was associated with lower odds of SCD after adjusting for age, total energy intake, major non-dietary factors, and specific dietary factors. Comparing the highest versus the lo...

研究目的：前瞻性探讨长期膳食类黄酮摄入与主观认知下降（subjective cognitive decline, SCD）的关联。
研究方法：本研究纳入护士健康研究（Nurses’ Health Study, NHS）1984至2006年间的49493名女性，以及健康专业人员随访研究（Health Professionals Follow-up Study, HPFS）1986至2002年间的27842名男性进行队列随访。采用泊松回归分析膳食类黄酮（包括黄酮醇、黄酮、黄烷酮、黄烷-3-醇、花青素、聚合类黄酮与原花青素）与后续主观认知下降发生的关联。对于NHS队列，长期平均膳食摄入量通过7次重复食物频率问卷（SFFQs）计算得出，主观认知下降分别于2012年和2014年完成评估；对于HPFS队列，平均膳食摄入量通过5次重复食物频率问卷计算得出，主观认知下降分别于2008年和2012年完成评估。
研究结果：在校正年龄、总能量摄入、主要非膳食因素及特定膳食因素后，总类黄酮摄入水平越高，主观认知下降的发生风险越低。将摄入量最高组与最低组进行对比……