The_molecular_epidemiology_of_Salmonella_Typhi_in_Kibera__Kenya. The_molecular_epidemiology_of_Salmonella_Typhi_in_Kibera__Kenya

The aim of the project is to provide whole genome sequencing data valuable to the surveillance of Salmonella Typhi in Kibera, an informal settlement in Nairobi, Kenya. The molecular epidemiological analysis forms part of an ongoing Population Based Infectious Disease Surveillance (PBIDS) platform, which is implemented by the Kenya Medical Research Institute (KEMRI) with oversight and support from the US Centers for Disease control and Prevention (CDC) Kenya office. Under PBIDS, ~25,000 Kiberia residents of all ages have been followed since 2006 by field workers who conduct household visits and collect data on recent illnesses, healthcare-seeking, and demographic details. PBIDS participants receive free medical care for acute illnesses at the Tabitha Clinic, where participants meeting the case definition for acute febrile illness or severe acute respiratory infection are eligibe for blood culture. Since 2007, ~350 cases of typhoid fever have been detected by culture. The programme will conduct an in-depth epidemiological, environmental, social, and molecular biological analysis to elucidate typhoid fever transmission dynamics in this population and help inform the strategic implementation of prevention interventions, including vaccination campaigns in this and other high-burden urban settings. 1) This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute please see http://www.sanger.ac.uk/datasharing/