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m6A-seq profiling in Xist and Xist_Del_A-repeat cell lines

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NIAID Data Ecosystem2026-03-11 收录
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By m6A-seq, we examined the m6A pattern on Xist and Xist_Del_A-repeat, which immediately after the A-repeat region. A-repeat deletion abolished the m6A methylation downstream the A-repeat but not the m6A peak located in Xist exon VII. Overall design: M6A profiling in cell lines with WT Xist or Xist lacking the A-repeat. We are aiming to understand how m6A pattern was on Xist and how m6A modification on Xist affect Xist-mediated chromosome silencing.

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2020-04-14
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