Non-lupus full-house nephropathy: a case series

Abstract Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune inflammatory disease. However, some patients may exhibit a histological pattern of kidney injury, with characteristics indistinguishable from lupus nephritis, but without presenting any extrarenal symptoms or serologies suggestive of SLE. Such involvement has recently been called non-lupus full-house nephropathy. The objective is to report a series of clinical cases referred to the Laboratory of the Federal University of Maranhão that received the diagnosis of "full-house" nephropathy unrelated to lupus, upon immunofluorescence and to discuss its evolution and outcomes. Non-lupus full-house nephropathy represents a diagnostic and therapeutic challenge, because it is a new entity, which still needs further studies and may be the initial manifestation of SLE, isolated manifestation of SLE or a new pathology unrelated to SLE.摘要 系统性红斑狼疮（Systemic lupus erythematosus, SLE）是一种慢性多系统自身免疫性炎症疾病。部分患者可出现与狼疮性肾炎（lupus nephritis）组织学特征难以鉴别的肾损伤病理表型，但无任何提示SLE的肾外症状或血清学异常。此类肾脏受累近来被命名为非狼疮性满堂亮肾病（non-lupus full-house nephropathy）。本研究旨在报告一组送检至马拉尼昂联邦大学（Federal University of Maranhão）实验室的病例：这些患者经免疫荧光（immunofluorescence）检测被诊断为与狼疮无关的"满堂亮"型肾病，并探讨其病程转归与结局。非狼疮性满堂亮肾病属于诊断与治疗难题，因其作为一种新型病种，目前仍需开展更多研究，且其既可能为SLE的初始表现、SLE的孤立性受累表现，也可能是一种与SLE无关的全新病理类型。