Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor

Protein Data Bank Japan2023-10-04 更新2026-03-21 收录

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Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor Descriptor: N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)prop-2-enamide, Reverse transcriptase/ribonuclease H, SULFATE ION, ... Authors: Chan, A.H, Kudalkar, S.N, Anderson, K.S. Deposit date: 2017-05-09 Release date: 2017-08-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

HIV-1逆转录酶（Reverse Transcriptase）Y181C突变体与非核苷类抑制剂（Non-nucleoside Inhibitor）N-(6-氰基-3-(2-(2-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)乙氧基)苯氧基)-4-甲基萘-1-基)丙烯酰胺（JLJ685）的晶体结构。描述项：N-(6-氰基-3-{2-[2-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)乙氧基]苯氧基}-4-甲基萘-1-基)丙-2-烯酰胺、逆转录酶/核糖核酸酶H、硫酸根离子…… 作者：Chan, A.H.、Kudalkar, S.N.、Anderson, K.S. 沉积日期：2017-05-09 发布日期：2017-08-23 最后修改日期：2023-10-04 实验方法：X射线衍射（2.5埃）引用文献：《用于根除耐药HIV-1逆转录酶的共价抑制剂：从设计到蛋白质晶体学》，《美国国家科学院院刊》，114卷，2017年

创建时间：

2017-05-09